Despite an increased expression of Cyp7a1 and reduced lipid levels in the CL–treated LDLR-deficient mice, we could not observe regression of atherosclerosis, unlike others have shown before with a simple dietary intervention switching from high-cholesterol diet to chow that led to improved systemic plasma glucose and lipid parameters [31,45,46,47]. The gene discussed is CYP7A1; the disease is atherosclerosis.