In human breast cancer cell lines, MCF-7 and MDA-MB 231, pimpinelol, a linear sequiterpene lactone from Pimpinella haussknechtii, has been shown to induce apoptosis by increasing protein aggregation and ER stress, as demonstrated by fluorescence microscopy analysis and by mRNA expression of ATF4, CHOP, GADD34, and tribbles-related protein 3 (TRIB3) [110]. The gene discussed is DDIT3; the disease is breast carcinoma.