The in vivo efficacy of antibiotic-laden 3D printed CaPS, Rif1%-PLGA40, Sita1%-PLGA40, and Rif1% + Sita1%-PLGA40 was assessed in a mouse femoral ostectomy model of implant-associated osteomyelitis utilizing a single-stage revision, as previously described [42]. Here, RIF1 is linked to osteomyelitis.