In recent years, B7-H3 has been extensively studied as a negative modulator in tumor immunity.[30] B7-H3 protein is expressed in many tumor tissues, such as lung cancer, gastric cancer, kidney cancer, prostate cancer, and neuroblastoma.[31,32] Studies on B7-H3 expression in gastric cancer have indicated that ectopic expression of B7-H3 is closely related to tumor progression and poor prognosis.[33,34] B7-H3 overexpression has been linked to poor prognosis in human patients and to the invasive and metastatic potential of tumors in vitro models. This evidence concerns the gene CD276 and lung cancer.