Compared with PD-L1 expression in tumor/parenchymal cells, the expression of B7-H3 in tumor/parenchymal cells was more strongly correlated with CD8-positive and CD68-positive cell infiltration, while B7-H4 expression was associated with the infiltration of immune cells only in stromal cells, and the localization of B7-H4 in tumor/parenchymal cells was more significantly associated with tumor progression. The gene discussed is CD274; the disease is neoplasm.