PLAT and intracranial hemorrhage: PAR-1 and PAR-2 play a role in modulating the effects of coagulation factors such as thrombin, factor Xa, and TPA and are associated with inflammation and neurodegeneration in stroke.[25] This mechanism may also explain why, after induced cerebral artery occlusion and reperfusion with r-TPA, Wistar rats on rivaroxaban had a significantly lower intracranial hemorrhage volume.[25]