Traumatic lower limb amputees have increased morbidity and mortality due to cardiovascular disease.[4,11] Several factors including insulin resistance and psychological stress may have systemic consequences in the arterial system and may contribute to increased cardiovascular morbidity in amputees.[6] Significant hypertension was observed in above-knee amputees.[12] Fortunately, our patient's blood pressure remained normal during pregnancy, and no cardiovascular disease was identified before delivery. This evidence concerns the gene INS and cardiovascular disorder.