To demonstrate SH3BP4 is transcriptionally regulated by Wnt, we analyzed the TCF7L2/TCF4 chromatin immunoprecipitation sequencing (ChIP-seq) data generated from two different human CRC cell lines, namely, Ls174T and HCT116 (ENCODE Project Consortium, 2012, Hatzis et al., 2008). The gene discussed is TCF7L2; the disease is colorectal carcinoma.