Given that Keratin 8 was found in 4 out of 5 plasma samples from ACS patients in the immune-peptidome analysis, provoked memory T cell response in high fat diet fed apoE-/- mice, and is functionally involved in immune responses based on citations discussed above, it was selected for translational studies using PBMCs collected from a spectrum of CAD patients. The gene discussed is APOE; the disease is coronary artery disorder.