Given that Keratin 8 was found in 4 out of 5 ACS plasma subjected to IP and UPLC-MS/MS, and the mouse peptide homolog induced a self-reactive Effector Memory T cell response in apoE-/- mice fed a high fat diet, we tested the translational potential of the findings by stimulating PBMC from CAD patients with the human Keratin 8 peptide. Here, APOE is linked to coronary artery disorder.