On the other hand, the inhibition of SOCS1 expression by a siRNA did no change the radiotherapy response in any of the six cell lines, and the isolated clonal resistant populations did not show any modification in the level of SOCS1 mRNA expression, indicating that SOCS1 is not directly related to radioresistance acquisition in GBM, as it was postulated by Zhou et al [18]. This evidence concerns the gene SOCS1 and glioblastoma.