IFNA1 and neoplasm: To examine if the response of tumor to lenvatinib was an important component in the response of the tumors to IFN signal activation [23], we divided the mice into two groups according to a mean of tumor sizes after 1 week of lenvatinib treatment: those with relatively lenvatinib-sensitive smaller tumors (LEN-S) and those with relatively larger tumors that were moderately sensitive to lenvatinib (LEN-L).