There was no significant association between an illness severity score of 2 to 3 versus 0 to 1 and presence of an out-of-reference-range test result for total T3, FT4, FT3, TSH, post-cosyntropin cortisol, endogenous ACTH, or having met the diagnostic criteria for hypothyroidism or hyperadrenocorticism (data not shown). This evidence concerns the gene POMC and Cushing syndrome.