TEAD1 and heart failure: Since the rise in body weight was far lower in the Tead1-cKO pups their normalized heart weight to body weight became significantly higher than the control flox littermates (8.075 ± 0.501 mg/g compared with 5.848 ± 0.100 mg/g, p = 0.0005), a finding consistent with their ongoing heart failure phenotype.