TEAD1 and heart failure: We had previously demonstrated that in adult cardiomyocytes Tead1 is a direct transcriptional regulator of Ppp1r1a (Inhibitor-1) and that loss-of-function of Tead1 leads to increased PP1 activity, decreased (PLN) phospholamban phosphorylation and consequent decrease in Serca2a activity, along with heart failure [11].