On univariate analysis (χ2/Fisher’s exact test), tumor size greater than 5 cm (P =.024), histologic grade III (P = .034), human epidermal growth factor receptor 2–positive status (P = 0.007), inner/central tumor quadrant location (P = 0.002), four or more positive ALNs in level I/II (P < .001), presence of perinodal extension (PNE; P < .001), and presence of lymphovascular space invasion (LVI; P < .001) were significantly associated with level III ALN metastases. The gene discussed is ERBB2; the disease is neoplasm.