Soeparwata etal.[10]and Mendoza et al.[9] found a positive correlation between the cardiacmyxoma size index (i.e., tumor volume) and circulating IL-6 levels.We assumed that, besides the relationship between tumor size (maximal dimension[length] and volume) and IL-6, there might also be close relations between IL-6 ordecrement (difference of pre- and postoperative values) of IL-6 (∆IL-6) andthe anatomic features of cardiac myxomas. This evidence concerns the gene IL6 and neoplasm.