Some studies showed that these mediators also affect regulation of the synthesis of C-reactive protein (CRP), another important inflammatory marker related to tissue injury and cardiovascular events.(13) In respect to the connection between the hyperglycemic state resulting from DM and inflammation, it is important to highlight the formation of advanced glycation products, which promote oxidative stress - particularly in visceral fat deposits - and the increased expression of immunoinflammatory mediators, such as IL-6. The gene discussed is IL6; the disease is diabetes mellitus.