Recent studies using an HD fly model found that increasing glial energy metabolism by over‐expressing uncoupling proteins, or modulating neuronal metabolism by over‐expression of Glut1 or G6PD in neurons can alleviate the pathology of flies transgenic for a pathogenic huntingtin protein (HD93Q) (Besson, Alegria, Garrido‐Gerter, Barros, & Lievens, 2015; Besson, Dupont, Fridell, & Lievens, 2010). This evidence concerns the gene HTT and Huntington disease.