INPP4A and familial pancreatic carcinoma: Among the eight top candidate variants, one has been reported to be a possible tumor suppressor gene: INPP4A. INPP4A has been shown to be downregulated in pancreatic cancer and to inhibit cell proliferation and promote apoptosis in bladder and pancreatic cancer cells (Wang, Feng, Jiang, & Zuo, 2017; Wang, Wu, Huang, & Chen, 2018).