CLSPN and cancer: In addition, we propose three candidate variants in known cancer susceptibility genes (BMPR1A, BRIP1, and SRC), up to three truncating variants in possibly novel cancer genes (CLSPN possibly SEC24B, SSH2), four missense variants in genes involved in cancer initiation or progression (ACACA, NR2C2, INPP4A, and DIDO1), and five candidate risk factor recessive genes (ATP10B, PKHD1, UGGT2, MYH13, TFF3).