ADAM17 and cancer: In an attempt to search for novel cancer genes, we identified 10 truncating variants (in addition to the pathogenic PTEN variant) (Table 2) in genes which are not known to be susceptibility genes for cancer: CLSPN, CELSR2, ADAM17, BIRC6, SEC24B, RBM27, PPARGC1B, NCOA7, SSH2, and MYO9B. All these genes are expressed in colon tissue (genecards.org).