DIDO1 regulates embryonic stem cell renewal (Liu et al., 2014) and is upregulated in melanoma tissues and cell lines as well as colorectal tumors (Braig & Bosserhoff, 2013; Sillars‐Hardebol et al., 2012), although in the latter, there was no correlation to gene copy number and DIDO1 was suggested to be a passenger on the common 20q duplication seen in CRC. Here, DIDO1 is linked to colorectal carcinoma.