In the brains of human tau‐overexpressing mice (3 months, Figure 1h–j; 12 months, Supporting Information Figure S2) and AD patients (Figure 1k,l), decreased expression of dynamin 1 was also detected, suggesting that tau overexpression impairs synaptic endocytosis by suppressing dynamin 1 transcription. The gene discussed is DNM1; the disease is Alzheimer disease.