Compared with the previous study on the expression profiles of lncRNAs in Aβ intracerebral injection AD rat models, several similar KEGG pathways such as insulin signaling pathway, synaptic vesicle cycle, cell adhesion molecules, and neuroactive ligand-receptor interaction were predicted [26], which may indicate an important role of these signaling pathways in neural system, as well as in the pathogenesis of AD. This evidence concerns the gene INS and Alzheimer disease.