Indeed, overexpression of integrin αV consequently leads to TGF-β overactivation in SSc dermal fibroblasts because of miR-29's involvement as a modulator of integrin's genes implicated in this pathway, as well as miR-142-3p, which directly regulates the expression of integrin αV, as stated by Li et al. [95], whose work is supported by Taniguchi's epigenetic study on bleomycin-induced skin fibrosis Fli-1 +/- mice, which proved latent TGF-β activation to be an αVβ3 integrin- and αVβ5 integrin-dependent mechanism [96]. Here, TGFB1 is linked to systemic sclerosis.