Promoting cell proliferation in prostate cancer cells (Prensner et al., 2011), effects on the transcriptional and post-transcriptional regulation of cytoskeletal and extracellular matrix genes in lung adenocarcinoma cells (Tano et al., 2010), repressing tumor suppressors INK4a/p16 and INK4b/p15 (Yap et al., 2010; Kotake et al., 2011) are postulated to be some of the mechanisms. Here, CDKN2B is linked to lung adenocarcinoma.