COL18A1 and hereditary angioedema: Controlled clinical trials, however, are needed to investigate whether treatment options used for HAE-C1-INH, such as BCX7353, avoralstat, ecallantide, conestat alfa, purified C1-INH and a recombinant antibody inhibiting kallikrein (lanadelumab), are also effective in HAE-nC1-INH [1, 7, 10–13].