The diagnostic workup of angioedema should exclude the possibility of acquired angioedema, i.e. ACE-inhibitor associated angioedema (ACEI-AAE), acquired C1-deficiency angioedema (C1-INH-AAE) and acquired non-histaminergic angioedema (InH-AAE) [15]. The gene discussed is ACE; the disease is acquired angioedema.