Analysis of Tet2-deficient (Tet2fl/flCd4-cre) CD8 T cells responding to infection with lymphocytic choriomeningitis virus (LCMV) showed increased LCMV gp33-specific memory precursor cells (KLRG1− CD127+) and decreased short-lived effector cells (KLRG1+ CD127−) on day 8 post-infection (42) (Figure 3G). Here, CD8A is linked to infection.