Very recently, the WDFY4 molecule, a member of the BEACH (Beige and Chediak-Higashi) domain–containing family of proteins, was reported to be specifically required for cross-presentation of cell-associated Ag by cDC1, and for cDC1-dependant immune control of the highly immunogenic 1969 regressor fibrosarcoma (52). The gene discussed is MPPE1; the disease is fibrosarcoma.