ITGAX and neoplasm: One major caveat of using CD11c for targeting DCs is that the gene encoding this molecule, Itgax, is expressed by other immune cell types, including some that play critical roles in anti-tumor immunity, such as NK cells, effector memory CTLs, intraepithelial lymphocytes (IELs), plasmablasts, and subsets of monocytes or macrophages (32).