It can determine the tolerogenic vs. immunogenic nature of tumor cell death (95–97), control the expression of the growth factors and chemokines promoting local recruitment, differentiation, expansion and survival of cDC1 or their progenitors (55, 93, 98), dampen cDC1 production of activating cytokines (56, 67), and inhibit their maturation or even polarize it toward tolerance (99, 100). This evidence concerns the gene MPPE1 and neoplasm.