A murine mononuclear phagocyte derived from B-1 cells treated with COX-2 inhibitors and infected with L. major presented lower numbers of intracellular amastigotes and reduced PGE2 and IL-10 release (Arcanjo et al., 2015), and macrophages infected with L. donovani induced COX-2 expression in a toll like receptor-2 (TLR2)-dependent-manner, favoring the infection in these cell types (Bhattacharjee et al., 2016). Here, PTGS2 is linked to infection.