Interestingly, both COX-2 inhibitors downmodulated IL-6 secretion regardless of infection compared to uninfected and untreated cells (P = 0.029) (Figure 5B), however in the presence of T. gondii, COX-2 inhibitors did not change the levels of IL-6 in comparison to untreated and infected cells (Figure 5B). This evidence concerns the gene PTGS2 and infection.