Also, COX inhibitors diminished the internalization of T. cruzi in mouse peritoneal macrophages (Malvezi et al., 2014) and human monocytes (Carvalho de Freitas et al., 2017), and COX-2 and PGE2 are mentioned as inductors of the immunosuppression observed during the acute phase of Chagas disease, favoring the persistence of the parasite in host cells (Pinge-Filho et al., 1999). The gene discussed is PTGS2; the disease is Chagas disease.