IGF2 and cancer: Increased cell proliferation, increased energy metabolism, evasion of growth suppressors, evasion of contact-inhibition, evasion of cell death, invasion, metastasis, and induction of angiogenesis are the hallmarks of cancer, but all of these processes are also normal and essential requirements for the development and morphogenesis that occur in early fetal life when IGF-II is the predominant metabolic regulator.