Loss of imprinting of IGF-II, in which both paternal and maternal alleles are expressed, increases the risk of developing colorectal cancers (122) and prostate cancers (123) presumably by setting a more growth-promoting and hence more fertile “soil.” Indeed, in a mouse model experimentally induced loss of imprinting of IGF-II in the prostate promoted widespread neoplasic growths (124). Here, IGF2 is linked to Familial prostate cancer.