However, despite the fact that GLP-1 receptor deficient animals present with alterations of bone composition (28), little is known about the action of GLP-1 receptor agonists on bone compositional parameters in T2DM, although changes in collagen and mineral properties have been suspected to play a role in the etiology of fragility fractures in T2DM. This evidence concerns the gene GLP1R and type 2 diabetes mellitus.