KLF1 and anemia (phenotype): In 2015, the first case of severe neonatal anemia with kernicterus due to KLF1 compound heterozygosis was described in man (Magor et al., 2015), with an erythroid phenotype largely mirroring that observed in mice: hydrops fetalis, hemolytic anemia, jaundice, hepatosplenomegaly, marked erythroblastosis and high levels of HbF.