For example, reduced levels of α-KG due to BCAA transaminase 1 (BCAT1) overexpression in acute myeloid leukemia (AML) cells were found to inhibit TET demethylase activity, thereby inducing DNA hypermethylation, which promoted AML cell survival and lead to decreased clinical outcome (Raffel et al., 2017). Here, BCAT1 is linked to acute myeloid leukemia.