IGF1R and dementia: Proportional hazard analyses of dementia incidence revealed that those in the lowest tertile of IGF-I receptor stimulating activity at baseline had the lowest risk of dementia [HR moderate vs. low: 1.45 (95% CI 1.00–2.12); HR high vs. low 1.40 (95% CI 0.96–2.04)], while there was no difference in risk of dementia between the medium and highest tertiles (Figure 1).