In those without the ApoE-ε4 variant, the level of IGF-I receptor stimulating activity was not associated with the risk of dementia (medium vs. low: HR 0.97 (95% CI 0.59–1.60); high vs. low: HR 1.09 (95% CI 0.67–1.77); χ2(2) = 0.24, p = 0.89). This evidence concerns the gene IGF1R and dementia.