APOE and dementia: Dementia risk was significantly increased in people with one or more copies of the ApoE-ε4 allele and IGF-1 receptor stimulating activity in the median and top tertiles compared to those with IGF-I receptor stimulating activity in the bottom tertile [medium vs. low: HR 3.80 (95% CI 1.90–7.60); high vs. low: HR 2.71 (95% CI 1.37–5.38)].