In a mouse model of chronic systemic inflammation, Drake et al. (2011) showed with histological experiments an intense recruitment of activated immune cells at ChPs, while in their parallel human study, they did not examine a potential uptake of the TSPO radiotracer 11C-PK11195 in ChPs of patients at risk of stroke, probably because of the expected “off-target” effect. Here, TSPO is linked to Stroke.