However, in the case of the recently developed Tau radiotracer flortaucipir (also known as [18F]AV-1451 or [18F]-T807), elevated ChP binding has attracted considerable interest because of ChP proximity (and potential signal contamination) to hippocampus, a key region for staging tauopathy in Alzheimer’s disease (AD) (Pontecorvo et al., 2017; Lee et al., 2018). This evidence concerns the gene MAPT and early-onset autosomal dominant Alzheimer disease.