AKT1 and cancer: The main involved KEGG pathways for the 13 high-confidence candidate genes were: metabolic pathways (hsa:01100), PI3K-Akt signaling pathway (hsa:04151), signaling pathways regulating pluripotency of stem cells (hsa:04550), thyroid hormone signaling pathway (hsa:04919), and pathways in cancer (hsa:05200) (Table 2 and Supplementary Table 10).