PDK4 and neoplasm: Rather consistent with our findings regarding PDK4 expression in liver tissue and CRLM, a recent study revealed that PDK4 expression was significantly more abundant in tumour-adjacent liver tissue than in primary liver tumours.28 In contrast to our findings, however, a previous translational study reported significantly up-regulated PDK4 mRNA expression within CRC tissue compared to healthy colon mucosa.29 This may in part be due to differences in patient characteristics between the two studies.