PDK4 and colonic neoplasm: Indeed, we could show that, firstly, PDK4 mRNA expression was significantly higher in healthy liver and colon mucosa compared to tissue derived from CRLM or primary colon tumours; that, secondly, increased hepatic expression of PDK4 represented an independent prognostic factor concerning overall survival of patients receiving NC; and, thirdly, that PDK4 expression was likewise associated with improved postoperative liver function in patients undergoing surgical resection of CRLM.