Within the given context, we could show that the loss of HIF prolyl-hydroxylase domain containing enzyme 1 (PHD1), one of the three ubiquitously expressed cellular oxygen sensors, protects murine livers from oxidative stress and liver failure in a model of acute ischaemia/reperfusion injury.18 Moreover, loss of PHD1 markedly reduced oxidative stress in murine peripheral muscle cells via pyruvate dehydrogenase kinase (PDK)-dependent metabolic reprogramming, thus providing protection against ischaemic stress.19 This evidence concerns the gene EGLN2 and Hepatic failure.