Treg cells also produce TGFβ as well as IL-12, which inhibit T cell proliferation and cytokine release, thereby dampening the immune response.80 This could represent a mechanism of conveying immune surveillance of a tumour, yet, the studies included in this review show contradicting result on the prognostic value of FOXP3+ cells. The gene discussed is TGFB1; the disease is neoplasm.