qPCR and Western-blot analyses of cultured human CRC cell lines (Caco-2, HT-29, RKO, HCT116, and HCT-8) also showed significantly higher CDCA5 expression in CRC cells than in fetal colonic mucosal cells (FHC) (Fig. 1e, f; P < 0.05). The gene discussed is CDCA5; the disease is colorectal carcinoma.