We also demonstrated that the RGD4C/AAVP‐Grp78 vector provides much longer lasting transgene expression than the RGD4C/AAVP‐CMV vector carrying a CMV promoter, in vitro and in vivo in subcutaneous GBM following intravenous administration (Kia et al, 2012). The gene discussed is HSPA5; the disease is glioblastoma.