Moreover, we demonstrated that safe anti‐cancer agents such as curcumin from natural sources, known for its ability to cross the BBB (Klinger & Mittal, 2016), have the potential to induce the RGD4C/AAVP‐Grp78 vector promoter in human primary gliomas, consistent with previous studies reporting induction of the Grp78 in cancer cells, by curcumin, through the UPR pathway (Kim et al, 2016). The gene discussed is HSPA5; the disease is glioma.