HSPA5 and neoplasm: Our hypothesis is that the RGD4C/AAVP diffusion within the tumors, dual targeting of both the tumor vasculature and tumor cells and induction of Grp78 promoter by TMZ could account for the therapeutic potential of RGD4C/AAVP‐Grp78‐HSVtk/GCV and TMZ combination against GBM.