HSPA5 and neoplasm: In contrast, although we observed an increase in Luc expression in mice that received the RGD4C/AAVP‐Grp78‐HSVtk plus GCV, the Luc signals were reduced compared to the control non‐targeted/AAVP‐Grp78‐HSVtk plus GCV (Fig 4A–C), proving an inhibitory effect on tumor growth and tumor viability.