Importantly, the phage capsid was engineered to display the CDCRGDCFC (RGD4C) ligand (Fig EV1A) that binds the heterodimer αvβ3 integrin cell surface receptor, which is overexpressed on tumor cells and supporting angiogenic vasculature in most tumor types including human GBM (Hajitou et al, 2006; Schnell et al, 2008). The gene discussed is CD177; the disease is neoplasm.