HSPA5 and central nervous system cancer: Moreover, we demonstrated that safe anti‐cancer agents such as curcumin from natural sources, known for its ability to cross the BBB (Klinger & Mittal, 2016), have the potential to induce the RGD4C/AAVP‐Grp78 vector promoter in human primary gliomas, consistent with previous studies reporting induction of the Grp78 in cancer cells, by curcumin, through the UPR pathway (Kim et al, 2016).