The Grp78 promoter is marginally active in healthy tissues; however, potent activation has been observed in aggressive tumors, including GBM (Dong et al, 2004; Pyrko et al, 2007; Virrey et al, 2008), and is induced by stress and conditions of tumor microenvironment such as glucose deprivation, chronic anoxia, and acidic pH. This evidence concerns the gene HSPA5 and glioblastoma.