HSPA5 and cancer: TMZ‐induced expression and activation of the endogenous GRP78 promoter have been reported in human glioblastoma (Pyrko et al, 2007; Virrey et al, 2008), and induction of Grp78 has been reported in various cancer therapies, including chemotherapy (Li & Lee, 2006; Lee, 2007; Pyrko et al, 2007; Virrey et al, 2008).