In line with this, we found that resistin, which possesses pro-inflammatory effects and contributes to IR and inflammation [32, 33], was reduced in F. Oppositely, FGF21 and adiponectin, two anti-inflammatory adipokines with insulin sensitizing properties and negatively correlated to obesity, were higher in F. Conversely, M showed a high level of pro-inflammatory markers and crown-like structure in both AT compared to F, despite a lower proportion of total body fat. Here, INS is linked to obesity due to melanocortin 4 receptor deficiency.