Vascular accumulation of amyloidogenic forms of Cystatin C, Gelsolin, Transthyretin, and prion protein are pathological hallmarks of Hereditary cystatin C amyloid angiopathy, Familial amyloidosis Finnish type, Familial transthyretin amyloidosis (FTA)-leptomeningeal form and prion protein-CAA, respectively [18, 24, 45, 52, 62]. The gene discussed is PRNP; the disease is amyloidosis.