Moreover, mice treated with T cells plus PD-L1 blocking antibody-treated TCM, also showed decreased tumor cell proliferation, and increased CD3+ T cell infiltration and IFN-γ production (Fig. 6c and d; Additional file 11: Figure S6a), as well as an increased production of cytolytic molecules perforin and granzyme B (Fig. 6e; Additional file 11: Figure S6b and c), compared with the mice treated with T cells plus TCM or control IgG-treated TCM. This evidence concerns the gene CD274 and neoplasm.