Notably, the downregulation of functional demethylating enzymes such as DNMT1, MBD3, and MBD4 resulted in lower levels of methylation at the promoter sites of sensitive genes implicated in SS leading to the overexpression of CD40L, CD11a, and CD70 as a relevant feature of SSc [96–98]. The gene discussed is CD40LG; the disease is systemic sclerosis.