Although we do not yet have direct evidence for cell-to-cell spread of pathology, the unexpected finding of intranuclear inclusions in NeuN-labelled neurons, particularly in the hypothalamus, opens the possibility for this type of transfer of pathology in our Gfa2-CGG99 mouse model of FXTAS. The gene discussed is RBFOX3; the disease is fragile X-associated tremor/ataxia syndrome.