Compared with the positive expression rate of WISP2 in esophageal normal mucosa tissues (Fig. 1A left panel) esophageal dysplasia tissues (Fig. 1A middle left panel), and esophagitis tissue (Fig. 1A middle right panel), WISP2 level in ESCC tissues was downregulated (Fig. 1A right panel). This evidence concerns the gene CCN5 and esophageal squamous cell carcinoma.