Contrasting the high frequency of dental abscesses in Hyp mice [211] with their relative absence in Phex- and Fgf23-normal hypophosphatemic mouse models [212] or in HHRH patients [213, 214] indicates that a phosphate-independent mechanism is likely to contribute to formation of dental abscesses in XLH. This evidence concerns the gene FGF23 and X-linked hypophosphatemia.