FGF23 and neoplasm: Nevertheless, resection of an FGF23-producing tumour has resolved muscle pain in a patient with TIO [128] and therapeutic application of an FGF23-blocking antibody has increased grip strength and spontaneous movement in Hyp mice [131] and led to full recovery of bone and muscle pain when treating patients with iron-induced FGF23-mediated hypophosphatemic osteomalacia [192].