Despite displaying hypophosphatemia and low serum calcitriol, mice with elevated FGF23 (Hyp or Fgf23-TG) did not develop skeletal abnormalities when CYP24A1 levels were repressed, either in Cyp24a1-null mutants or following blocking with CTA102 [15]. Here, CYP24A1 is linked to hypophosphatemia.