FBXO22 and neoplasm: Moreover, the results indicated that tumors developed from HLF-shFBXO22 cells were significantly smaller (p<0.05, Student’s t-test) and lighter (p<0.05, Student’s t-test) than tumors derived from control cells (Fig. 2g), Similarly, orthotopic tumor developed from HLF-shFBXO22 cells were also significantly smaller (p<0.05, Student’s t-test) than tumors derived from control cells (Fig. 2h), which was related to the decreased cell proliferation rate due to the downregulation of FBXO22.