In our stratified analysis, 4 groups of carcinomas had been evaluated repeatedly: the pooled AUC of GDF-15 to rule out PC, EC, GC, and HCC were estimated to be 0.82, 0.84, 0.90, and 0.85, respectively, showing that GDF-15 testing achieved a significant level of efficacy in confirming GC. Here, GDF15 is linked to pachyonychia congenita.