Analysis of secondary endpoints at Week 40, including percentage change from baseline in UPDRS motor score in the ON state, UPDRS ADL and total scores in both OFF and ON state, and UPDRS parts I and IV, as well as change from baseline in Parkinson’s disease diary ratings, did not reveal any significant difference between the GDNF and placebo treated groups (Table 2). The gene discussed is GDNF; the disease is Parkinson disease.