IRS1 and cancer: In line withthis, the expression and phosphorylation of IRS1 has been determined in numerouscell lines, and trends toward increased expression or phosphorylation of IRS1 havebeen reported in many cancers (Bergman etal., 1996; Rocha etal., 1997; Schnarret al., 2000; Hoanget al., 2004; Kodaet al., 2005; Hanet al., 2006; Ravikumar et al., 2007; Sisci et al., 2007)