As the tumor metastatic potential is a result of the balance between MMPs and TIMP-2, which plays a role in invasion by stimulating the degradation of the extracellular matrix (ECM) in CRC cells, these findings are logical, as we also established that CDH2 or N cadherin, an EMT marker, was directly regulated by miR-495. The gene discussed is TIMP2; the disease is colorectal carcinoma.