CFTR and cystic fibrosis: However all significant loci reported at the SLC26A9 locus in [12] are in linkage disequilibrium with rs7549173 (S3 Table), including rs7512462 which has been used as an instrumental variable in a Mendelian Randomization analysis of CF-related diabetes and shown to associate with exocrine pancreas disease [15] and CFTR-directed therapeutics response [2].