PRSS1 and pancreatitis: A follow-up study [38] further showed that rs4726576 (chr7:142457132, 186bp upstream of PRSS1; S3 Table), a variant in high LD with both GWAS study-associated variants (rs3757377 and rs10273639), is contributing to the pancreatitis relationship by directly influencing gene expression levels based on reporter gene assays in acinar pancreatic cells.