Support for CFTR (min p = 2.34x10-5 at rs213972; gene-based permutation p = 0.0001; S2 Fig) and the association between the apical plasma membrane gene-set and meconium ileus was also observed in this study (permutation p<1x10-4 in a subset of 5,869 unrelated individuals from the full consortium data and p = 0.017 in the North American Phase II subgroup alone). The gene discussed is CFTR; the disease is intestinal obstruction in the newborn due to guanylate cyclase 2C deficiency.