The SLC6A14 rs3788766 was the most significant SNP in this (Table 2, panel (a) in Fig 2) and our previous meconium ileus GWAS [12] (S3 Table), and its risk allele T corresponds to increased transcript level based on the GTEx eQTL data of adult pancreas tissue (panel (a) in Fig 2). Here, SLC6A14 is linked to intestinal obstruction in the newborn due to guanylate cyclase 2C deficiency.