At the PRSS1 locus, the meconium ileus associated SNP, rs3757377 (Table 2, Chr7:142455538, 1.8kb 5’ of the TSS, OR = 1.29, p = 2.55x10-7; S5 Fig) is in high LD (r2 = 0.71 and D’ = -0.99) with rs10273639, the variant that was identified in a GWAS of alcoholic-related chronic pancreatitis in Europeans [37]. This evidence concerns the gene PRSS1 and intestinal obstruction in the newborn due to guanylate cyclase 2C deficiency.