CD4 and systemic lupus erythematosus: On the other hand, the specific expression of T cell modules in patients with SLE are in agreement with findings regarding hypomethylation of type I interferon genes in naive CD4+ T cells [20], and the findings on the type II IFN dysregulation mentioned in section I. These results suggest that type I interferon T cell signaling, possibly secondary to IFN-g-induced signaling, might contribute to the development of SLE.